Gaining the High Ground over Evolutionism acknowledges the profoundly ideological nature of the question of origins. Moving beyond the limits of scientific inquiry alone, it approaches the subject by tracing the scientific revolution and its far-reaching influence on Western thought, examining interpretive approaches to Genesis 1, and surveying significant developments in the histories of geology, biology, and astronomy.

O'Keefe explains how science is framed as a disciplined way of knowing and clarifies how the scientific method functions within natural history. He evaluates the court system's role in addressing the controversy, draws on C. S. Lewis's critique of naturalism, and challenges the philosophical assumptions underpinning evolutionary science. In doing so, he offers what he believes to be the most compelling arguments against the ideology of naturalism, and thereby against evolutionism. Ultimately, he calls readers back to the enduring authority of Scripture and highlights the meaningful partnership between reason and faith-inviting thoughtful seekers to explore both with integrity and hope.

Expanding the scope of inquiry beyond the confines of science, O'Keefe shows that the idea of a creator needs to be attended with more seriousness than post-Enlightenment science and philosophy have ever thought necessary.