This volume focuses on the broad application of whole genome amplification (WGA) in cancers, preimplantation genetic testing, and forensic science. The chapters in this book cover topics such as upstream challenges (sample preparation, quality control) and downstream applications (next-generation sequencing, SNP detection). This book also explores how WGA's have impacted fields like cancer genomics (detecting subclonal mutations), prenatal testing (non-invasive aneuploidy screening), and microbiome research (amplifying low-biomass communities). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Whole Genome Amplification: Methods and Protocols is a valuable resource for all researchers who are looking to learn more about this important and advancing field. Chapter 13 is available Open Access under a Creative Commons Attribution 4.0. International License via link.springer.com.