This book constitutes the proceedings of the 7th Mediterranean Conference on Information Systems, MCIS 2012, held in Guimaraes, Portugal, in September 2012.MCIS 2012 comprised theories, research, and practices based on knowledge management and innovations in organizations, society, and businesses. The 18 full papers presented in this volume were carefully reviewed and selected from 89 submissions. They are organized in topical sections on: emerging and innovative information systems, enterprise systems and enterprise engineering, Web 2.0 enabled business models, information quality management and data accuracy in innovative IS, and ICT applications in healthcare.