This book constitutes the refereed joint proceedings of the First International Workshop on Data Driven Treatment Response Assessment, DATRA 2018 and the Third International Workshop on Preterm, Perinatal and Paediatric Image Analysis, PIPPI 2018, held in conjunction with the 21st International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2018, in Granada, Spain, in September 2018. The 5 full papers presented at DATRA 2018 and the 12 full papers presented at PIPPI 2018 were carefully reviewed and selected. The DATRA papers cover a wide range of exploring pattern recognition technologies for tackling clinical issues related to the follow-up analysis of medical data with focus on malignancy progression analysis, computer-aided models of treatment response, and anomaly detection in recovery feedback. The PIPPI papers cover topics of advanced image analysis approaches focused on the analysis of growth and development in the fetal, infant and paediatric period.