This book presents a multidisciplinary evidence-based approach to the management of teeth with lesions of endodontic-periodontal origin. The book opens by addressing the etiology and classification of endodontic-periodontal lesions, and demonstrates its relevance to the daily practice. Specific endodontic, prosthetic, and periodontal considerations that should be incorporated into clinical decision making and treatment planning are then discussed in detail. Subsequent chapters describe modern clinical procedures in periodontal regenerative treatment, describe vertical root fractures as an endodontic-periodontal lesion, examine treatment alternatives following the extraction of teeth with endodontic-periodontal lesions, and discuss possible biological complications in implant supported oral rehabilitation. Finally, a summary chapter considers the integration of clinical factors and patient values into clinical decision making. The text is accompanied by many figures presenting informative clinical examples. The authors are internationally renowned scientists and clinicians from the specialties of Endodontology, Periodontology, and Oral Rehabilitation. Owing to its multidisciplinary and comprehensive nature, the book will be relevant and interesting to the entire dental community.